Parotid saliva 1 H-NMR analysis for colon cancer metabolomics: A case report.
Identifieur interne : 000006 ( Main/Exploration ); précédent : 000005; suivant : 000007Parotid saliva 1 H-NMR analysis for colon cancer metabolomics: A case report.
Auteurs : Angela Rovera [Royaume-Uni] ; Mark Hector [Royaume-Uni] ; Paul Anderson [Royaume-Uni]Source :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [ 1754-4505 ] ; 2021.
Abstract
BACKGROUND
A key priority in colon cancer research is the identification of molecular biomarkers to improve early diagnosis, guide prognosis, and the design of new therapeutic approaches. Saliva is a powerful diagnostic biofluid that can be used to detect systemic alterations. This study aimed to investigate the parotid saliva (PS) metabolic Proton Nuclear Magnetic Resonance (
CASE REPORT
We describe the
CONCLUSION
PS
DOI: 10.1111/scd.12635
PubMed: 34293207
Affiliations:
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uniqKey="Hector M" first="Mark" last="Hector">Mark Hector</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, University of Dundee, Dundee, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Dentistry, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Paul" sort="Anderson, Paul" uniqKey="Anderson P" first="Paul" last="Anderson">Paul Anderson</name><affiliation wicri:level="4"><nlm:affiliation>Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region 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last="Rovera">Angela Rovera</name><affiliation wicri:level="4"><nlm:affiliation>Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Hector, Mark" sort="Hector, Mark" uniqKey="Hector M" first="Mark" last="Hector">Mark Hector</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, University of Dundee, Dundee, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Dentistry, University of Dundee, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Paul" sort="Anderson, Paul" uniqKey="Anderson P" first="Paul" last="Anderson">Paul Anderson</name><affiliation wicri:level="4"><nlm:affiliation>Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></analytic><series><title level="j">Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</title><idno type="eISSN">1754-4505</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>A key priority in colon cancer research is the identification of molecular biomarkers to improve early diagnosis, guide prognosis, and the design of new therapeutic approaches. Saliva is a powerful diagnostic biofluid that can be used to detect systemic alterations. This study aimed to investigate the parotid saliva (PS) metabolic Proton Nuclear Magnetic Resonance (</p></div><div type="abstract" xml:lang="en"><p><b>CASE REPORT</b></p><p>We describe the </p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>PS </p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">34293207</PMID><DateRevised><Year>2021</Year><Month>07</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1754-4505</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2021</Year><Month>Jul</Month><Day>22</Day></PubDate></JournalIssue><Title>Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</Title><ISOAbbreviation>Spec Care Dentist</ISOAbbreviation></Journal><ArticleTitle>Parotid saliva <sup>1</sup> H-NMR analysis for colon cancer metabolomics: A case report.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/scd.12635</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A key priority in colon cancer research is the identification of molecular biomarkers to improve early diagnosis, guide prognosis, and the design of new therapeutic approaches. Saliva is a powerful diagnostic biofluid that can be used to detect systemic alterations. This study aimed to investigate the parotid saliva (PS) metabolic Proton Nuclear Magnetic Resonance (<sup>1</sup> H-NMR) profile of a patient diagnosed with colon cancer, and the subsequent changes 1 year after the end of chemotherapy.</AbstractText><AbstractText Label="CASE REPORT" NlmCategory="METHODS">We describe the <sup>1</sup> H-NMR PS spectrum of a 65-year-old woman diagnosed with colon cancer (G3 pT3 pN1c) (T0), and the changes in the spectrum from PS collected 1 year after the end of chemotherapy (XELOX: capecitabine plus oxaliplatin) (T1). The data was co-analyzed with blood test cancer antigens (S-CEA; S-CA19-9) and thyroid peroxidase antibody (TPOAb) measurements obtained simultaneously in order to identify peaks and interpret the spectra. The blood cancer antigens (S-CEA; S-CA19-9) and the PS <sup>1</sup> H-NMR peaks for fatty acids, lactate, acetate, N-acetyl sugars, citrate, tyrosine, saccharides, and formate decreased at T1 compared to T0. Whereas, the thyroid peroxidase antibody (TPOAb) blood values increased at T1 compared to T0 reflecting the changes in the <sup>1</sup> H-NMR spectral window of 1-3.5 ppm.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">PS <sup>1</sup> H-NMR profiling identified modified metabolites that revealed cancer cells metabolism disturbances that subsequently decreased with time throughout treatment. These altered metabolites are potential biomarkers, providing a molecular diagnostic approach for clinical diagnosis, and prognosis of human colon cancer.</AbstractText><CopyrightInformation>© 2021 Special Care Dentistry Association and Wiley Periodicals LLC.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rovera</LastName><ForeName>Angela</ForeName><Initials>A</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7673-8253</Identifier><AffiliationInfo><Affiliation>Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hector</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>School of Dentistry, University of Dundee, Dundee, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>07</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Spec Care Dentist</MedlineTA><NlmUniqueID>8103755</NlmUniqueID><ISSNLinking>0275-1879</ISSNLinking></MedlineJournalInfo><CitationSubset>D</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">1H-NMR analysis</Keyword><Keyword MajorTopicYN="N">colon cancer</Keyword><Keyword MajorTopicYN="N">saliva</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="revised"><Year>2021</Year><Month>07</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="received"><Year>2021</Year><Month>06</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>07</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>7</Month><Day>22</Day><Hour>17</Hour><Minute>36</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">34293207</ArticleId><ArticleId IdType="doi">10.1111/scd.12635</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Tanaka T, Tanaka M, Tanaka T, Ishigamori R. 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Oncol Rep. 2013;30(4):1802-1806.</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rovera, Angela" sort="Rovera, Angela" uniqKey="Rovera A" first="Angela" last="Rovera">Angela Rovera</name></region><name sortKey="Anderson, Paul" sort="Anderson, Paul" uniqKey="Anderson P" first="Paul" last="Anderson">Paul Anderson</name><name sortKey="Hector, Mark" sort="Hector, Mark" uniqKey="Hector M" first="Mark" last="Hector">Mark Hector</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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